Arestat-T™ - for stabilisation of proteins against heat damage
Arestat-T™ offers bespoke stabilisation of proteins based on their structure, and can be used to prolong the shelf-life of proteins.
A panel of excipients is used to protect the dissolved protein when it is in an aqueous solution. The technology is based on protecting the protein against any detrimental effect caused by continuous exchange of protons between the protein and its aqueous environment.
The excipients are 'generally regarded as safe' (GRAS) and, therefore, can be easily incorporated into standard manufacturing processes without additional regulatory hurdles. The excipients provide an optimum proton-exchange environment. This narrows the range of conditions that the protein experiences in equilibrium with the surrounding environment at a given temperature. This means that fewer molecules at any one time are experiencing the ‘extreme’ or ‘rare’ states from which inactivation occurs.
See also Arestat-R™ - for stabilisation of proteins against ionising radiation
Last updated: 13 June 2008