Advanced delivery of biologics

Arecor Strengthens the Patent Portfolio of its Formulation Technology for the Development of Novel Vaccine and Gene Therapy Products

Cambridge, UK., 07 November 2017: Arecor Ltd (“the Company”), the UK-based leading formulation technology company, focussed on developing superior biopharmaceuticals via the innovative reformulation of proteins and peptides enabling the improved treatment of diabetes and other conditions, is pleased to announce that the Company has received notification from both the European and US Patent Offices of their intention to grant Arecor patent protection for the Company’s novel approach to enabling stable liquid adenovirus formulations.

Adenovirus vectors or virus materials that can be utilised to deliver new genes safely into the cells of the human body to trigger a therapeutic effect, are becoming increasingly important in the development of novel vaccine and gene therapy products. Unfortunately, adenovirus vectors are often very labile or changeable in aqueous compositions and they can lose potency very rapidly during storage. This loss of potency significantly limits their use in commercial products. Application of Arecor’s proprietary technology however overcomes the stability issues and enables the development of viable adenovirus-based therapies for a variety of conditions.

“We are delighted to announce this ‘intention to grant’ of a patent that protects our novel adenovirus stabilisation approach. This is an important addition to our growing patent portfolio, which further strengthens our position as a world leader in the formulation of superior biotherapeutics and vaccines”, said Dr Jan Jezek, Chief Scientific Officer at Arecor. “Our novel technology that enables the development of adenovirus vectors with superior stability is a good example of Arecor’s capability to expand into new, important and fast-developing areas”.

Arecor has developed a novel proprietary approach to formulating adenovirus products which ensures their stability during long-term storage, including storage outside the cold chain. Adenovirus products are used therapeutically for the treatment of conditions such as cancer or they can be used as vaccines to prevent infections such as HIV or tuberculosis.

Patent Portfolio

Arecor’s technology is protected by 20 patent families, including 22 granted patents, and the intention to grant of the
adenovirus stabilisation patents is an important addition to an already impressive portfolio. Arecor has been
exploiting its technology in partnerships with pharmaceutical companies, successfully developing superior product
profiles, including stable high-concentration antibodies with low viscosity, reformulations of lyophilised or freezedried
products into stable liquids or stable vaccines that can be used outside the cold chain. Arecor’s technology has
been shown numerous times to succeed where other approaches fail. The successful development of a heat-stable
formulation of *Hepatitis B vaccine for use in hot climatic zones, is one such example of the utility of the technology.

*(For further info, please see: Jezek et al. A heat-stable hepatitis B vaccine formulation. Human Vaccines 5(8), 529-535, 2009; Jones Braun et al.
Characterization of a thermostable hepatitis B vaccine formulation. Vaccine 27, 4609-4614, 2009.)

*** ENDS ***

For more information, please contact:

Arecor Limited

Dr Sarah Howell, Chief Executive

Tel: +44 (0) 1223 426 060

Peckwater PR

Tarquin Edwards

Tel: +44 (0) 7879 458 364

About Arecor
Arecor Ltd is a leader in developing superior biopharmaceuticals through the application of an innovative formulation technology platform. Arecor is currently leveraging this platform to develop a portfolio of proprietary products that will enable improved treatments for diabetes via the innovative reformulation of approved proteins and peptides. Arecor's product portfolio also includes:

· Stable aqueous glucagon for emergency and artificial pancreas use,
· Novel insulin formulations to deliver ultra-rapid acting insulin analogs and;
· Ultra-concentrated rapid acting insulin to enable the miniaturisation of devices.

In addition to its internal product portfolio, Arecor partners with leading pharmaceutical and biotech companies to deliver superior reformulations of their proprietary products, which would otherwise not be possible using conventional formulation science.