Partner
Insense Ltd is a specialty woundcare company who have developed Oxyzyme™ a novel woundcare dressing. This was the first application of Arecor's stabilization technology.
This revolutionary dressing is composed a hydrogel bi-layer in which is suspended glucose oxidase and a glucose substrate. The glucose oxidase utilizes atmospheric oxygen converting the glucose substrate to gluconic acid and hydrogen perioxide providing a continuous supply of reactive oxygen directly onto the wound. This kills infections and facilitates the healing of chronic wounds.
Problem
The activity of the enzyme glucose oxidase in the wound dressing was lost after sterilization through exposure to 25kG of gamma radiation. The enzyme activity was also needed to be stable after storage at ambient temperature for up to two years.
Strategy
A combination of Arestat-R™ and Arestat-T™ technology was used to stabilize the glucose oxidase in hdyrogel and provide a wound dressing with a commercially viable shelf-life.
Results
• The glucose oxidase in the wound dressing retained almost full activity immediately following irradiation and upon storage.
• The product has been approved in the EU and Canada. It has been granted a shelf life of three years at ambient temperature.